RAGE、S100A8和S100P在良性前列腺增生和前列腺癌组织中的表达

摘要

Objective To investigate the expressions and clinical significance of the receptor for advanced glycation end‐products (RAGE ) and its ligands S100A8 and S100P in benigne prostate hypertrophy(BPH) and prostate cancer(PC) tissues .Methods Immunohistochemical method was employed to examine the expressions of RAGE and its ligands S100A8 and S100P in 32 PC patients . The expressions in BPH and PC were compared .Results The expressions of RAGE ,S100A8 and S100P in PC tissues were significantly higher than those in BPH(P<0 .05) .The expression of RAGE in PC tissues was related to prostate‐specific antigen(P<0 .05) .The expressions of RAGE ,S100A8 and S100P in PC tissues were closely related to TNM and clinical stages(P<0 .05 ) .The expression of RAGE was possitively correlated to that of S100A8 and S100P(P<0 .05) .Conclusion RAGE and its ligands S100A8 and S100P may participate in the development ,invasion and metastasis of PC and could become the targets for the diagnosis and treatment of PC .%目的：探讨晚期糖基化终末产物受体（RAGE）及其配体钙粒蛋白 A8（S100A8）和钙粒蛋白P（S100P）在良性前列腺增生（BPH）和前列腺癌组织中的表达及临床意义。方法应用免疫组化方法检测30例BPH组织和32例前列腺癌组织中RAGE及其配体S100A8和S100P的表达，并结合临床资料进行统计学分析。结果与BPH比较，前列腺癌组织RAGE及其配体S100A8和S100P的表达明显升高。RAGE的表达与前列腺癌患者术前前列腺特异性抗原（PSA ）水平有关（P＜0．05）；RAGE及其配体 S100A8和 S100P 的表达与前列腺癌的临床和肿瘤分期密切相关（P＜0．05）；RAGE分别与S100A8和S100P结合，在前列腺癌组织中的表达呈正相关（P＜0．05）。结论 RAGE及其配体S100A8和S100P可能参与了前列腺癌的发生、发展、浸润和转移，三者有可能成为前列腺癌诊断和治疗的新靶点。