老年高血压病与骨质疏松症及维生素D水平的相关性分析

摘要

Objective To investigate the correlation of hypertension with osteoporosis and vitamin D in the elderly.Methods A total of 403 physical examination people aged more than 65 years old was divided into two groups of A(with essential hypertension,224 cases)and B(with normal blood pressure,179 cases).The blood pressure,bone mineral density(BMD)and serum 25-hydroxyvitamin D [25-(OH)D]levels were recorded.The correlation of BMD and 25-(OH)D with other related factors was analyzed in group A.Results The prevalence of osteoporosis in group A was higher than that in group B(45.1% vs.35.2%)(P<0.05).The values of BMD of lumbar vertebrae,femoral neck,Ward's triangle and the femoral greater trochanter in group A were lower than those in group B(P<0.01). The serum 25-(OH)D level in group A was lower than that in group B[23.31 ± 10.17)nmol/L vs. (30.26 ± 12.68)nmol/L](P<0.01).Pearson correlation analysis showed that BMD of the lumbar vertebrae was negatively correlated with SBP and pulse pressure in the elderly with hypertension (r= -0.121 and -0.117,P<0.01).And serum 25-(OH)D level was negatively correlated with age, SBP,DBP and pulse pressure(r= -0.022,-0.118,-0.091 and -0.116,P<0.05).Conclusion The risk of osteoporosis is increased and serum 25-(OH)D level is decreased in elderly patients with essential hypertension.%目的 探讨老年高血压病患者与骨质疏松症(OP)及血清维生素D水平的关系.方法老年体检者403例中,患高血压病的224例(A组),血压正常者179例(B组).比较两组血压、骨密度和血清25-羟维生素D[25-(O H)D]水平,分析A组患者骨密度及血清25-(O H)D与其他因素的相关性.结果 A组OP患病率高于B组(45.1% vs.35.2%)(P<0.05).A组腰椎、股骨颈、Ward's三角和股骨大转子的骨密度均低于B组(P<0.01).A组血清25-(O H)D水平低于B组[(23.31 ± 10.17)nmol/L vs.(30.26 ± 12.68)nmol/L](P<0.01).Pearson相关分析显示,A组腰椎骨密度与SBP、脉压水平呈负相关(r= -0.121、-0.117,P<0.01);其血清25-(O H)D与年龄、SBP、DBP、脉压水平亦呈负相关(r= -0.022、-0.118、-0.091、-0.116,P<0.05).结论 合并高血压病的老年患者血清25-(O H)D水平降低,发生OP的风险增加.