东莞市2010年387例药品不良反应报告分析

摘要

Objective To investigate the characteristics correlation with influencing factor of adverse drug reaction.Methods Collected 387 cases adverse drug reaction reports which were from six hospital in Dongguan city from January2010 to January2011,acorrding to the age,sex,route of medication,reporter,grade of adverse drug reaction,causation of the adverse drug reaction,the kind of the medicine,clinical manifestation of adverse drug reaction and so on,and to he statistical analysis.Results In 387 cases adverse drug reaction reports,anti-infectious agent drug of the adverse drug reaction was 123 cases,31.78 percent,it was the fewest,and then the Chinese drugs preparation had 70 cases,18.09 percent,it was the second one; The intravenous injection was the main route of medication which was arousing the adverse drug reaction,it was 299,77.26 percent;The common clinical manifestation of the adverse drug reaction was the appendages of the skin damaged,was 211 cases,54.52 percent.Conclusions The clinician should be enhance training the knowledge of adverse drug reaction,the monitoring of adverse drug reaction were the anti-infectious agent drug and Chinese drugs preparation,it was important,use the drug with reason and criterion,abatement and avoid the adverse drug reaction happened again,to be insure to safe medication.%目的 探讨东莞市药品不良反应发生的特点及相关影响因素.方法 对东莞市6家镇医院2010年1月-2011年1月上报的387例药品不良反应报告,按照患者的年龄、性别、给药途径、报告人、药品不良反应的等级、药品不良反应的因果关系、引发药品不良反应的药品种类、药品不良反应的主要临床表现等方面进行统计分析.结果 387例药品不良反应报告中,抗感染药物所引起的药品不良反应最多者123例占31.78％,其次为中药制剂70例占18.09％,静脉注射是引发药品不良反应的主要给药途径有299例占77.26％,药品不良反应最为常见的临床表现为皮肤及附件损害有211例占54.52％.结论 对临床医生应加强药品不良反应知识的培训,抗感染药物、中药制剂是不良反应监测的重点,合理规范用药,减少或避免药品不良反应的重复发生,确保用药安全.