辣椒碱柔性脂质体三种给药途径的镇痛作用研究

摘要

目的 探讨辣椒碱柔性脂质体三种给药途径的镇痛作用和时效关系.方法 观察辣椒碱柔性脂质体不同给药途径对冰醋酸引起的小鼠扭体反应次数的影响及对小鼠痛阈的影响(热板法).结果 辣椒碱柔性脂质体三种给药途径均可减少小鼠扭体次数,提高痛阈.辣椒碱柔性脂质体注射给药15分钟起效,口服给药维持时间大于180分钟.结论 辣椒碱柔性脂质体注射给药起效快,维持时间短;辣椒碱柔性脂质体口服给药起效慢,维持时间长.%Objective To investigate the analgetic action and time-effect relationship of capsaicin plexible liposomes on three administration pathway.Methods Mice in the experimental groups were administrated in abdomen injection, stomach gavage and topical skin to be used for writhing and hot-plate tests.Result The capsaicin plexible liposomes could restrict the writhing response and prolong the pain threshold of mouse remarkably, the onset time of capsaicin was 15min in injections and the persistent time of capsaicin was longer than 180min in stomach gavage.Conclusion The effect of capsaicin plexible liposomes, administrated in abdomen injection, is faster than others and administrated in stomach gavage,can continue for long.