多囊卵巢综合征与胰岛素抵抗的研究

摘要

Objective To observe the effect of metformin combined with ovulation in treatment of polycystic ovary syndrome(PCOS)with insulin resistant ovulation rate and pregnancy rate.Methods 50 patients were randomly divided into group A and group B.Two groups were treated with clomiphene ovulation,group B was given metformin additionally,statistics analysis were carried out in two groups after treatment including ovulation rate,pregnancy rate and abortion rate,serum progesterone and insulin levels were compared.25 cases with normal insulin were selected as group C,B and C groups were compared with clomiphene ovulation induction(CC)of the PCOS patients randomly selected from insulin normal ovulation rate,pregnancy rate and abortion rate were compared between the two groups at the same time of blood progesterone insulin levels.Results Group A ad B treatment of monitoring indicators for the difference was statistically significant(P＜ 0.05).There was no statistical significant difference in indicators between the groups of B and C.Conclusions Metformin combined with ovulation may improve insulin resistance in patients with PCOS ovulation rate,pregnancy rate and reduce abortion rate after pregnancy,it is an effective method in treatment regimens for insulin resistance in PCOS patients.%目的 观察二甲双胍联合促排卵治疗多囊卵巢综合征合并胰岛素抵抗者排卵率及妊娠率的影响.方法 50例患者随机分为对照组(A)和观察组(B),每组25例.两组病例均采用氯米酚促排卵治疗,B组在此基础上同时服用二甲双胍,治疗后统计两组患者排卵率、妊娠率及流产率,比较两组血孕酮和胰岛素水平.随机选取胰岛素正常的多囊卵巢综合征患者25例作为C组,BC两组比较用氯米酚(CC)促排卵治疗后排卵率、妊娠率及流产率,比较两组同时的血孕酮和胰岛素水平.结果 AB两组治疗后各项监测指标比较差异有显著性(P＜0.05).BC两组间各项指标检测均无显著性(P＞0.05).结论 二甲双胍联合促排卵可提高胰岛素抵抗的PCOS患者的排卵率、妊娠率,降低妊娠后流产率,是胰岛素抵抗的PCOS患者的一个有效的治疗方案.