妊娠高血压综合征患者的同型半胱氨酸与超敏C反应蛋白检测水平的相关性探讨

摘要

目的 研究血浆同型半胱氨酸(Hcy)与超敏C反应蛋白(HsCRP)的联合测定对妊娠高血压综合征(妊高症)患者病情诊断的价值,探讨Hcy与HsCRP在妊高症的相关性.方法 选取妊高症患者116例,包括轻度妊高征40例、中度妊高征40例、重度妊高征36例.随机抽取正常晚孕患者40例作为正常晚孕对照组,采用循环酶法检测血浆同型半胱氨酸(Hcy),免疫比浊法测定超敏C反应蛋白(HsCRP).结果 轻度、中度、重度妊高征患者Hcy、HsCRP与正常晚孕对照组比较差异有统计学意义(P＜0.01)；妊高征组的Hcy与HsCRP的相关性回归曲线估计趋近直线,呈正相关.结论 Hcy与HsCRP都是妊高症的危险因素评估指标,两者呈正相关,并与病情的严重程度呈正相关,有效反映妊高症的病情进展变化.Hcy与HsCRP联合检测对妊高症的早期分析、发展及预后都起到指导意义.%Objective To study plasma homocysteine (Hcy) and high sensitive C reaction protein (HsCRP) of the joint determination of pregnancy-induced hypertension syndrome (PIH) patients in the diagnostic value of Hcy and HsCRP,in correlation of PIH syndrome.Methods 116 cases of patients with PIH were divided into 3 groups:40 cases of mild PIH,40 cases of moderate PIH,36 cases of severe PIH.Randomly selected normal late pregnant patients and 40 cases of normal late pregnant control group by enzymatic cycling method for detection of plasma Hcy,serum HsCRP immunoturbidimetric assay.Results In PIH group,mild,moderate,severe PIH syndrome in patients with Hcy and normal late pregnant group showed significant differences (P＜0.01); in PIH group,mild,moderate,severe PIH syndrome in patients with HsCRP and normal late pregnant group were significantly different (P＜0.01);correlation between Hcy and HsCRP mild,moderate,severe PIH group regression curve estimation,like a straight,positive correlation.Conclusions Hcy and HsCRP are PIH risk factors evaluation indexes,correlation regression curve estimation,like a straight,positively correlated,and positively related to the severe degree,effectively reflect the progress of PIH disease.The combined detection of Hcy and HsCRP is early PIH analysis,development and prognosis has guiding significance to the project.