中药配方治疗脑卒中伴顽固性呃逆的疗效观察

摘要

Objective To provide support for clinical treatment by observing the efficacy of a traditional Chinese medicine formula for refractory hiccups associated with stroke and the effect of this formula in the prevention of complications.Methods 97 patients with stroke associated with refractory hiccups were randomly divided into a study group and a control group by using the random number remainder grouping method.The study group (48patients) received therapy with a traditional Chinese medicine formula,while the control group (49 patients) received intramuscular injections of metoclopramide.One week after treatment,the efficacy ofthe therapies and the incidence rates of constipation,respiratory infections,gastrointestinal bleeding,and renal and hepatic dysfunction were observed and compared between the two groups.Results The total effectiveness rate was significantly better in the study group (89.58％) than in the control group (P＜0.01),with a significant statistical difference.The incidence rates of constipation,infections respiratory,gastrointestinal bleeding,and hepatic dysfunction were significantly lowered in the study group than in the control group (2.08％ vs.24.49％,2.08％ vs.16.33％,4.17％ vs.20.41％,and 2.08％ vs.16.33％; P＜0.05),with significant statistical differences.There was no significant statistical differences in the rate of renal dysfunction between the two groups (8.33％ vs.8.16％,P＞0.05).Conclusions This Chinese medicine formula is efficacious in the treatment of refractory hiccups and in the prevention of complications in stroke patients.%目的 观察一种中药配方治疗脑卒中伴顽固性呃逆的疗效及其预防并发症的效果,为临床治疗提供依据.方法 将97例脑卒中伴顽固性呃逆患者采用随机数余数分组法将患者分成实验组及对照组,实验组49例应用中药配方水煎服服用,对照组48例应用甲氧氯普胺肌注,观察两组患者用药一周后的情况,比较两组治疗顽固性呃逆的显效情况、便秘的发生率、呼吸道感染率、消化道出血、肾功能损害、肝功能损害等.结果 脑卒中伴顽固性呃逆患者实验组的总有效率达89.58％,明显优于对照组(P＜0.01),差异有统计学意义.便秘(2.08％ vs24.49％)、呼吸道(2.08％vs 16.33％)、消化道出血(4.17％vs 20.41％)、肝功能损害(2.08％ vs 16.33％)发生率较对照组明显减少,差异有统计学意义(P＜0.05),而两组间肾功能损害发生率差异比较无统计学意义(8.33％ vs 8.16％,P＞0.05).结论 该中药配方能有效治疗脑卒中伴顽固性呃逆患者,有效预防并发症的发生.