肥胖型与非肥胖型多囊卵巢患者的内分泌特点及临床治疗方案分析

摘要

Objective To analyze the characteristics of endocrine and metabolic in obese women and nonobese women with polycystic ovary syndrome (PCOS) and the corresponding therapeutic regimen.Methods 86 patients with PCOS who had visited our hospital during January 2009 to May 2012 were divided into obesity group and non-obesity group according to the BMI.Impaired glucose tolerance,insulin resistance,insulin area under the curve,and therapeutic regimen were compared between the two groups.Results Rate of insulin resistance was obviously higher in the obesity group than in the non-obesity group (P＜0.05).Combination therapy was more effective than monotherapy in those with insulin resistance (P＜0.05).Conclusions Most obese patients with PCOS have insulin resistance,and so have a considerable number of nonobese patients.Combination therapy is more efficacious than monotherapy.%目的 分析肥胖型与非肥胖型多囊卵巢综合征(PCOS)患者的内分泌、代谢特征及相应的治疗方案.方法 根据患者体重指数将2009年1月至2012年5月于我院就诊的86例多囊卵巢综合征患者分为肥胖组与非肥胖组,对比分析两组患者糖耐量受损、胰岛素抵抗、胰岛素曲线下面积,及其给予的治疗方案.结果 肥胖组患者胰岛素抵抗率明显高于非肥胖组患者,有胰岛素抵抗的患者联合用药比单用药效果更明显,且各项指标差异均有统计学意义(P＜0.05).结论 肥胖型患者大多数存在胰岛素抵抗,非肥胖型患者亦有相当患者存在胰岛素抵抗,联合用药比单用药效果更明显.