辛伐他汀治疗老年高脂血症的使用剂量及其疗效研究

摘要

Objectives To explore the dosage and efficacy of simvastatin for hyperlipidemia in elderly patients.Methods 94 elderly hyperlipidemia patients were randomly divided into a large dosage group and a small dosage group,47 cases for each group.These two groups were treated with simvastatin 20 mg/d and 10 mg/d,respectively.The efficacies of both groups were observed.Results All lipid indicators were enormously better in the large dosage group than in the small dosage group after the treatment (P ＜ 0.05).The efficacy was 95.74％ in the large dosage group and was 82.98％ in the small dosage group (P ＜ 0.05).There was no statistical difference in the incidence of adverse reactions between the two groups (P ＞ 0.05).Conclusions Large dosage (20 mg/d) of simvastatin for elderly hyperlipidemia patients is quite effective and safe.%目的 探讨辛伐他汀治疗老年高脂血症的使用剂量及疗效.方法 将94例老年高脂血症患者随机分为大剂量组和小剂量组,各47例,分别给予20 mg/d与10 mg/d辛伐他汀治疗,观察两组治疗疗效.结果 大剂量组治疗后各血脂指标均优于小剂量组(P＜0.05);大剂量组治疗总有效率为95.74％,显著高于小剂量组的82.98％ (P＜0.05);两组患者不良反应发生率比较,差异无统计学意义(P＞0.05).结论 大剂量(20 mg/d)辛伐他汀治疗老年高脂血症疗效显著,安全性好.