等效均匀剂量在肺癌患者放疗中的应用

摘要

Objective To analyze the equivalent biological dose of three dimensional conformal radiotherapy for patients with lung cancer and to investigate its effect on adverse reactions of radiotherapy for patients.Methods 80 patients with lung cancer who underwent three dimensional conformal radiotherapy in our hospital from June 2013 to June 2014 were divided into group A and group B with 40 cases in each group.Both two groups received equivalent biological dose of radiotherapy.The dose of group A was 65-75 Gy, with the average of 72 Gy;while that of group B was 86-100 Gy, with the average of 90 Gy.Both two groups were treated with conventional chemotherapy regimens for 4 periods after radiotherapy and followed up for 1 year.The clinical effect was compared between two groups and the incidence of radioreactions at early or late stage in two groups were statistically analyzed.Results In group A, there were 10 cases of complete remission and 12 cases of partial remission, the total effective rate of radiotherapy was 55.0％;while in group B, there were 29 cases of complete remission and 7 cases of partial remission, the total effective rate of radiotherapy was 90.0％;with statistically significant difference between two groups (P＜0.05).The incidence of radioreactions at early or late stage in group A was 42.5％, while that in group B was 52.5％, without statistically significant difference between two groups (P＞0.05).Conclusion To set the equivalent biological dose of three-dimensional conformal radiotherapy for lung cancer to about 90 Gy can improve the control rate of tumor and will not increase the incidence of radiation injury,with high safety, worthy of promotion.%目的 分析肺癌患者作三维适形放疗的等效生物剂量,探讨其对肺癌患者放疗不良反应的影响.方法 将2013年6月至2014年6月我院收治的接受三维适形放疗的80例肺癌患者分为A、B两组,每组40例.两组均接受等效生物剂量放疗,A组剂量为65 ～ 75 Gy,平均72 Gy,B组剂量为86 ～ 100Gy,平均90 Gy,两组均在放疗结束后采用常规化疗方案治疗4个周期,随访1年,比较两组临床效果,统计两组早晚期放射性反应发生率.结果 A组完全缓解10例,部分缓解12例,放疔总有效率为55.0％,B组完全缓解29例,部分缓解7例,放疗总有效率为90.0％;两组放疗效果对比差异有统计学意义(P＜0.05).A组早晚期放射性反应发生率为42.5％,B组发生率为52.5％,两组发生率对比差异无统计学意义(P＞ 0.05).结论 将肺癌三维适形放疗等效生物剂量设定为90 Gy左右,可提高肿瘤控制率,同时不会增加放射性损伤发生率,安全性高,值得推广.