恩再适对膝关节骨关节炎患者血TNF-α的影响

摘要

Objective To observe the effect of Analgecine on serum TNF-α in patients with knee osteoarthritis (KOA).Methods 96 patients with KOA were randomly divided into control group and experimental group.Control group underwent super laser irradiation 10 min,2 times a day;oral loxoprofen sodium 60 mg,3 times a day.Experimental group underwent Analgecine 7.2 U in 250 ml 0.9％ sodium chloride injection intravenous injection,1 time a day.The course of treatment was two weeks for both two groups.Results Clinical efficacy after treatment of two groups were both satisfactory;clinical efficacy 1 month after treatment of experimental group was better than that of control group.Serum TNF-αt level after treatment in both two groups significantly decreased (P＜0.01),and that in experimental group was lower than that in control group (P＜0.01);1 month after treatment,serum TNF-α level in control group increased (P＜0.01),but still lower than that before treatment,that in experimental group did not change significantly.Conclusion Analgecine can effectively reduce serum TNF-α level in patients with KOA.%目的 观察恩再适对膝关节骨关节炎(KOA)患者血肿瘤坏死因子-α(TNF-α)的影响.方法 96例KOA患者随机均分为对照组及实验组,对照组超激光局部照射10 min,1日2次;口服洛素洛芬钠60 mg,每日3次.实验组将恩再适7.2 U加入0.9％氯化钠注射液250 ml中静滴,每日1次.两组患者均连续治疗两周.结果 治疗结束后两组患者均取得了较好的疗效,但1个月后,实验组疗效优于对照组.两组患者血TNF-α治疗结束后明显下降(P＜0.01),且实验组低于对照组(P＜0.01);1个月后,对照组升高但仍低于治疗前(P＜0.01),实验组变化不明显.结论 恩再适可有效降低KOA患者血TNF-α水平.