西格列汀对妊娠期糖尿病患者餐后血糖异常的控制效果

摘要

Objective To study the effect of sitagliptin for controlling postprandial blood glucose in patients with gestational diabetes mellitus.Methods 80 patients with gestational diabetes mellitus treated our hospital from June,2013 to June,2015 were selected as sutdy objects and were randomly divided an observation group and a control group,40 cases for each group.The observation group were treated with sitagliptin and the control group insulin.The fasting blood glucose (FPG) and postprandial blood glucose before and after the treatment and the incidence of adverse reactions during the treatment compared between these two groups.Results There were no statistical differences in FPG and 2hPG between these two groups before the treatment (P ＞ 0.05).2,4,and 6 weeks after the treatment,the 2hPG were (10.16±1.58)mmol/L,(9.23±1.78)mmol/L,and (8.86±1.25) mmol/L in the observation group and were (12.25±1.66)mmol/L,(11.44±1.79)mmol/L,and (10.13±1.44)mmol/L in the control group,respectively (P＜0.05).2,4,and 6 weeks after the treatment,the FPG were (8.06±0.85) mmol/L,(7.63±0.59)mmol/L,and (6.78±0.43)mmol/L in the the observation group and were (9.81±0.36)mmol/L,(8.02±0.49)mmol/L,and (7.01±0.37)mmol/L in the control group,respectively (P＜0.05).During the treatment,2 cases got hypoglycemia and 1 nausea in the observation group and 1 hypoglycemia and 1 vertigo in the control group,with no statistical difference (P＞0.05).Conclusions Sitagliptin can effectively control postprandial blood suger level in patients with gestational diabetes mellitus and has low adverse reaction rate,so it is worth being clinically generalized.%目的 研究西格列汀对妊娠期糖尿病患者餐后血糖(2hPG)异常的控制效果.方法 选取本院2013年6月至2015年6月80例妊娠期糖尿病患者为研究对象,抽签随机分为观察组与对照组,每组40例.观察组采用西格列汀治疗,对照组单用胰岛素治疗,比较两组治疗前后空腹血糖(FPG)、餐后血糖水平及治疗期间的不良反应发生率.结果 观察组与对照组治疗前FPG、2 hPG比较差异无统计学意义(P＞0.05),治疗后2、4、6周观察组2 hPG分别为(10.16±1.58) mmol/L、(9.23±1.78)mmol/L、(8.86±1.25)mmol/L,显著低于对照组的(12.25±1.66)mmol/L、(11.44±1.79)mmol/L、(10.13±1.44)mmol/L (P＜0.05).治疗后2、4、6周观察组FPG分别为(8.06±0.85) mmol/L、(7.63±0.59) mmol/L、(6.78±0.43) rnmol/L,显著低于对照组的(9.81±0.36) mmol/L、(8.02±0.49) mmol/L、(7.01±0.37)mmol/L (P＜0.05).治疗过程观察组低血糖2例,恶心1例;对照组低血糖1例,眩晕1例,两组比较差异无统计学意义(P＞0.05).结论 西格列汀可以有效地控制妊娠期糖尿病患者的餐后血糖水平,不良反应率低,值得临床应用和推广.