Objective To investigate the effect of early treatment on pregnancy outcomes in pregnant women with subclinical hypothyroidism (SCH).Methods A total of 88 pregnant women with SCH were enrolled in this study,and were divided into control group and observation group according to randomized double-blind method,44 cases in each group.The patients in the control group did not take any measures,the patients in the observation group were given early drug treatment.Compared pregnancy outcomes,the incidence of complications,and changes in thyroid hormone levels of the two groups.Results The level of TSH in the observation group at prenatal 1 week was (3.28 ±0.62)μIU/ml,which was significantly lower than that in the control group [(7.49±0.89)μIU/ml] (t=25.75,P＜0.05).The incidence of complications after treatment,the incidences of adverse pregnancy outcomes,abnormal glucose metabolism during pregnancy,and hypertension in the observation group were 9.09％,20.45％,9.09％,and 2.27％,respectively,those in the control group were 27.27％,81.82％,29.55％,and 11.36％,respectively,with statistically significant differences between the two groups (x 2=4.89,33.15,5.91,3.88;P＜0.05).Conclusion Early administration of levothyroxine sodium can effectively improve the pregnancy outcomes of pregnant women with SCH,reduce the incidences of complications,abnormal glucose metabolism during pregnancy,and hypertensive disorders,with significant clinical effect,worthy of clinical promotion.%目的 探讨妊娠合并亚临床甲状腺功能减退症(SCH)患者早期治疗对妊娠结局的影响.方法 对本院收治的88例妊娠期合并SCH的患者进行分组研究,按照随机双盲法分为对照组和观察组,每组44例.对照组患者未采取任何措施,观察组患者给予早期药物治疗,对比两组患者妊娠结局、并发症发生率以及甲状腺激素水平变化.结果 产前1周,观察组患者TSH水平为(3.28±0.62)μIU/ml,显著低于对照组的(7.49±0.89)μIU/ml(t=25.75,P＜ 0.05).观察组患者治疗后并发症发生率、不良妊娠结局、妊娠期糖代谢异常和高血压病症的发生率分别为9.09％、20.45％、9.09％和2.27％,对照组的分别为27.27％、81.82％、29.55％和13.64％,组间相比差异有统计学意义(x2=4.89,33.15,5.91,3.88;P＜0.05).结论 妊娠合并SCH产妇早期给予左甲状腺素钠治疗可以有效改善患者的妊娠结局,减少并发症的发生率和妊娠期糖代谢异常和高血压病症的发生率,临床效果显著,具有临床推广价值.
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