艾拉光动力疗法联合丹参酮胶囊治疗中度痤疮的疗效观察

摘要

Objective To study the efficacy and safety of 5-aminolevulinic acid gel (trade name:Ira) -photodynamic therapy (ALA-PDT) combined with tanshinone capsules in the treatment of moderate acne.Methods A total of 133 patients with moderate acne treated in department of dermatology from June 2015 to January 2017 were selected,and randomly divided into three groups.41 cases in control group A were treated with tanshinone capsules,46 cases in control group B were treated with ALA-PDT,46 cases in observation group were treated with ALA-PDT and tanshinone capsules.Compared the clinical effect of the three groups.Results After 4 weeks of treatment,the total effective rate was 84.78％ in the observation group,significantly higher than 36.59％ in the control group A and 56.52％ in the control group B (x 2=21.389 4,8.859 3;P＜0.05),the total effective rate in the control group B was significantly higher than that in the control group A (x 2=3.457 9,P＜0.05).Conclusions ALA-PDT combined with tanshinone capsules in the treatment of moderate acne has good clinical effect,moderate injury,short recovery time,and high safety,which provides a safe,effective,and ideal treatment for primary hospitals,worthy to be popularized.%目的 探讨5-氨基酮戊酸凝胶(商品名:艾拉)-光动力疗法(ALA-PDT)联合丹参酮胶囊治疗中度痤疮的有效性与安全性.方法 选择2015年6月至2017年1月期间惠州市皮肤病防治研究所皮肤科收治的中度痤疮患者133例,并随机分为3组,对照A组41例给予丹参酮胶囊治疗,对照B组46例给予5-氨基酮戊酸光动力疗法(ALA-PDT)治疗,观察组46例给予5-氨基酮戊酸光动力疗法(ALA-PDT)联合丹参酮胶囊治疗.比较3组的临床效果.结果 治疗4周后,观察组总有效率为 84.78％,显著高于对照A组的36.59％及对照B组的56.52％(x2=21.389 4、8.859 3,P＜0.05),对照B组总有效率56,52％明显高于对照A组的36.59％(x2=3.457 9,P＜0.05).结论 艾拉光动力疗法联合丹参酮胶囊治疗中度痤疮具有较好的疗效,损伤小,恢复时间短,安全性高,为基层医院提供了一种安全、有效、理想的治疗方法,值得临床推广.