脑苷肌肽辅助治疗对急性脑梗死患者神经功能及日常生活能力的影响

摘要

Objective To observe the impact of brain glycosides carnosine auxiliary treatment on neural function and the activity of daily living of patients with acute cerebral infarction.Methods 100 patients with acute cerebral infarction were randomly divided into 2 groups according to the random number table method.The control group (n=50) was treated with reducing intracranial pressure,nutrition of nerve cells,anticoagulant,and other symptomatic and supportive therapy,the observation group (n=50) was treated with brain glycosides camosine injection on the basis of the control group,and the course of two groups was 14 d.The clinical curative effect,Barthel index,NIHSS score before and after treatment of two groups were compared.Results The total effective rate of observation group was significantly higher than that of control group (96.0％ vs.78.0％,P＜0.05).There were no statistically significant differences in Barthel index,NIHSS score between the two groups before treatment (P＞0.05),Barthel index of the two groups increased significantly after treatment (P＜0.05),and NIHSS score decreased significantly (P＜0.05),Barthel index,NIHSS score of the observation group increased or decreased more significantly (P＜0.05).Conclusion Brain glycosides camosine auxiliary treatment can obviously improve neural function and daily life ability of patients with acute cerebral infarction.%目的 观察脑苷肌肽辅助治疗对急性脑梗死患者神经功能及日常生活能力的影响.方法 100例急性脑梗死患者根据数字表法随机分为两组,对照组(n=50)予以降低颅内压力、营养神经细胞、抗凝血等对症支持治疗,观察组(n=50)在对照组治疗基础上加用脑苷肌肽注射剂,两组疗程均为14d.比较两组临床疗效及治疗前后Barthel指数、NIHSS评分变化.结果 观察组治疗总有效率明显高于对照组(96.0％比78.0％,P＜0.05);两组治疗前Barthel指数、NIHSS评分比较差异无统计学意义(P＞0.05),两组治疗后Barthel指数明显升高(P＜0.05),NIHSS评分明显降低(P＜0.05),观察组治疗后Barthel指数、NIHSS评分较对照组升高或降低更为显著(P＜0.05).结论 脑苷肌肽辅助治疗可明显改善急性脑梗死患者神经功能及日常生活能力.