卡前列素氨丁三醇联合缩宫素预防高危妊娠产后出血的疗效及对血流动力学的影响

摘要

Objective To analyze the curative effect of the combination of carboprost tromethamine in the prevention of postpartum hemorrhage of high risk pregnancy and its effect on hemodynamics.Methods 86 patients with high-risk pregnancy treated at our hospital from September,2013 to August,2016 were divided into an observation group (n=43) and a control group (n=43) using random number table method.After childbirth,the control group were treated with oxytocin and the observation group carboprost tromethamine and oxytocin.The efficacies (the incidence of postpartum hemorrhage),the hemodynamics indexes before and 2 and 24 h after delivery [heart rate (HR),diastolic blood pressure (DBP),systolic blood pressure (SBP)],and the incidence of adverse reactions were compared between these two groups.Results The incidence of postpartum hemorrhage was 2.33％ (1/43) in the observation group and was 20.93％ (9/43) in the control group,with a statistical difference (x2=7.242,P ＜ 0.05).2 hours after delivery,the HR was lower and the SBP and DBP were higher in the observation group than in the control group,with statistical differences (P ＜ 0.05).24 hours after childbirth,the SBP was higher in the observation group than in the control group,with a statistical difference (P ＜ 0.05).The incidence of adverse reactions was lower in the observation group than in the control group (4.65％ vs.20.93％),with a statistical difference (x2=5.108,P ＜ 0.05).Conclusion The combination of carboprost tromethamine and oxytocin in the prevention of postpartum hemorrhage of high risk pregnancy is effective;and the blood flow dynamics of the pregnant woman is stable;it safe and reliable;so and it is worth being generalized.%目的 分析卡前列素氨丁三醇联合缩宫素预防高危妊娠产后出血的疗效及其对患者血流动力学的影响.方法 选取本院2013年9月至2016年8月收治的86例高危妊娠患者,采用随机数字表法分为观察组(n=43)和对照组(n=43),胎儿娩出后,对照组给予缩宫素,观察组给予卡前列素氨丁三醇和缩宫素,比较两组疗效(产后出血发生率)与分娩前、分娩后2h、分娩后24 h血流动力学指标[心率(HR)、舒张压(DBP)、收缩压(SBP)]及不良反应发生情况.结果 观察组产后出血发生率为2.33％,低于对照组产后出血发生率(20.93％),差异有统计学意义(x2=7.242,P＜0.05);观察组分娩后2hHR低于对照组,DBP、SBP高于对照组,差异均有统计学意义(均P＜0.05);观察组分娩后24 h SBP高于对照组,差异有统计学意义(P＜0.05);观察组不良反应发生率为4.65％,低于对照组(20.93％),差异有统计学意义(x2=5.108,P＜ 0.05).结论 卡前列素氨丁三醇联合缩宫素能够有效预防高危妊娠产后出血发生,保持产妇血流动力学处于稳定状态,安全可靠,值得推广使用.