评价不同炮制方法的半夏对老年单纯收缩期高血压患者血压的影响

摘要

Objective To compared the difference of clinical effect of pinellia processed by different methods in the treatment of elderly patients with isolated systolic hypertension,summary the optimized pinellia processing method.Methods Clinical data of 120 elderly patients with isolated systolic hypertension treated in the outpatient of our hospital from July 2015 to June 2016 was retrospectively analyzed.All patients were treated with Huangqi Xianxiong capsules whose main component was pinellia.Based on different pinellia processing methods,120 patients were divided into raw pinellia group,rhizoma pinelliae group,prepared pinellia tuber group,40 cases in each group.The changes of systolic blood pressure (SBP),diastolic blood pressure (DBP),and pulse pressure (PP) after treatment among three groups were observed,and evaluated the effect of adjustment on pinellia processing method on blood pressure.Results The improvement degree of SBP,DBP,and PP in raw pinellia group after 8 weeks' treatment were better than those in rhizoma pinelliae group,prepared pinellia tuber group (P＜0.05).The total effective rate in raw pinellia group was 92.5％,significantly higher than those in rhizoma pinelliae group,prepared pinellia tuber group (85.0％,82.5％) (P＜0.05).Conclusion ① Different pinellia processing methods have different effects on blood pressure in elderly patients with isolated systolic hypertension.② The processing method based on raw pinellia make the reduction of SBP and PP of patients with isolated systolic hypertension to the high-point,which can also make DBP stable,the processing mode has certain research and promotion value.%目的 分析不同炮制方法的半夏对于治疗老年单纯收缩期高血压患者疗效差异,总结最优化的半夏炮制方法.方法 将2015年7月至2016年6月本院住院门诊收治的120例老年单纯收缩期高血压患者临床资料进行回顾性分析,均给予以半夏为主要成分的黄芪陷胸胶囊治疗.基于半夏炮制方式的不同,将120例病例分成生半夏组、清半夏组和法半夏组各40例,重点观察3组病例治疗后收缩压(SBP)、舒张压(DBP)及脉压(PP)等血压指标的变化,评估调整半夏炮制方式对血压的影响.结果 生半夏组治疗8周后SBP、DBP及PP改善效果均要优于清半夏组和法半夏组(P＜0.05).生半夏组总有效率为92.5％,明显高于清半夏组和法半夏组的85.0％和82.5％ (P＜0.05).结论 ①半夏炮制方法不同对老年单纯收缩期高血压患者血压有着不同的影响;②基于生半夏的炮制方法入药能使单纯收缩期高血压患者收缩压和脉压减小达至最佳状态,同时还能稳定舒张压,该炮制方式具有一定的研究推广价值.