电光性眼炎的临床特点及重组人表皮生长因子滴眼液的治疗效果分析

摘要

Objective To explore the clinical features of electric ophthalmia and the therapeutic effect of recombinant human epidermal growth factor (rhEGF) eye drops. Methods 86 cases of electric ophthalmia were randomly divided into the treatment group and the control group with 43 cases in each group. The treatment group was treated with rhEGF eye drops combined with dicaine, while the control group was treated with erythromycin ointment combined with dicaine. The clinical features including gender, age, nosogenesis, and clinical manifestations of 86 patients were analyzed, and the curative effect and disappearance time of clinical symptoms were compared between the two groups. Results the majority of patients with electric ophthalmia were men under the age of 40 years old, mostly caused by welding light burn, and the common clinical manifestations were conjunctival congestion and edema, severe eye pain, photophobia and so on. The total effective rate in the treatment group was higher than that in the control group (95.35％ vs.81.40％) (P<0.05), and the disappearance times of conjunctival congestion, eyelid edema, pain, and photophobia in the treatment group were shorter than those in the control group [(5.23±1.14)h vs.(6.85±1.26)h, (6.37±1.28)h vs.(7.46±1.35)h, (10.58±2.03)h vs.(12.36±2.17)h, (12.42±2.35)h vs.(13.69±2.46)h] (P<0.05). Conclusions Electric ophthalmia mainly occurs in the young or middle aged men taking welding light burn as the main cause, and the common symptoms are conjunctival congestion and edema, severe eye pain, photophobia and so on. The rhEGF eye drops can effectively improve the patients' clinical symptoms, with definite and rapid efficacy.%目的 探究电光性眼炎的临床特点及重组人表皮生长因子(rhEGF)滴眼液的治疗效果.方法 将86例电光性眼炎患者随机分为治疗组和对照组,各43例.治疗组患者予以rhEGF滴眼液联合地卡因治疗,对照组患者予以红霉素眼膏联合地卡因治疗.分析86例患者的性别、年龄、致病原因、临床表现等临床特点;比较两组患者疗效及临床症状消失时间差异.结果 电光性眼炎患者以40岁以下的男性居多,多因电焊光烧伤致病,常见临床表现为结膜充血水肿、眼睛剧烈疼痛、畏光等.治疗组患者总有效率95.35％ 高于对照组81.40％,差异有统计学意义(P<0.05);结膜充血消失时间、眼睑水肿消失时间、疼痛消失时间、畏光消失时间(5.23±1.14)h、(6.37±1.28)h、(10.58±2.03)h、(12.42±2.35)h均短于对照组(6.85±1.26)h、(7.46±1.35)h、(12.36±2.17)h、(13.69±2.46)h,差异有统计学意义(P<0.05).结论 电光性眼炎患者具有多发于中、年轻男性,以电焊光烧伤为主要致病原因的临床特点,常见症状有结膜充血水肿、眼睛剧烈疼痛、畏光等;rhEGF滴眼液可有效改善患者的临床症状,疗效明确且迅速.