Objective To explore the effect of Diammonium Glycyrrhizinate injection combined with tiopronin on serum levels of alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (ALB), and quality of life in patients with chronic hepatitis B. Methods 147 patients with chronic hepatitis B in our hospital from February 2015 to April 2017 were selected, and were divided into the study group, the control group A, and the control group B according to the random number table method, 49 cases in each group. The control group A was treated with Diammonium Glycyrrhizinate injection, the control group B was treated with tiopronin, and the study group was treated with Diammonium Glycyrrhizinate injection combined with tiopronin. The treatment effect and adverse reactions of the three groups were observed and analyzed. The changes of serum ALT, TBIL, ALB levels and quality of life were compared among the three groups before and after treatment. Results The total effective rate of the study group was 91.84％, much higher than 61.22％ of the control group A and 71.43％ of the control group B, with statistically significant difference (χ 2=12.641, P<0.05). Before treatment, there were no statistically significant differences in serum ALT, TBIL, ALB levels, and the score of quality life among the three groups (F1=0.178, F2=0.016, F3=0.287, F4=0.331; P>0.05). After treatment, one-way analysis of variance showed that there were statistically significant differences in serum ALT, TBIL, ALB levels, and the score of quality life among the three groups (F1=31.751, F2=4.018, F3=9.808, F4=0.719; P<0.05); LSD-t test showed that the serum levels of ALT and TBIL in the study group were lower than those in the control group A and B, serum level of ALB and the score of quality life were higher than those in the control group A and B, with statistically significant differences (P<0.05), there were no statistically significant differences in serum ALT, TBIL, ALB levels, and thescore of quality life between the control group A and B (P>0.05). There were no statistically significant differences in the incidences of elevated blood pressure, headache, and injection site pain among the three groups (χ 21=2.056,χ 22=0.414, χ 23=1.014; P>0.05). Conclusion Diammonium Glycyrrhizinate injection combined with tiopronin can significantly reduce the serum levels of ALT and TBIL in patients with chronic hepatitis B, improve serum ALB level, further improve the treatment effect, and improve the quality of life, with high safety.%目的 探究甘草酸二铵注射液联合硫普罗宁对慢性乙型肝炎患者血清谷丙转氨酶(ALT)、总胆红素(TBiL)、白蛋白(ALB)水平变化及生活质量的影响.方法 选取2015年2月至2017年4月本院慢性乙型肝炎患者147例,依据随机数表法分为研究组、对照A组、对照B组,各49例.对照A组予以甘草酸二铵注射液治疗,对照B组予以硫普罗宁治疗,研究组予以甘草酸二铵注射液+硫普罗宁治疗.观察统计3组治疗效果、药物不良反应,并对比治疗前后3组血清ALT、TBiL、ALB水平及生活质量变化情况.结果 研究组治疗总有效率远高于对照A组、对照B组(91.84％ 比61.22％、71.43％),差异有统计学意义(χ2=12.641,P<0.05);治疗前,3组血清ALT、TBiL、ALB水平、生活质量评分比较差异均无统计学意义(F1=0.178,F2=0.016,F3=0.287,F4=0.331,均P>0.05),治疗后,经单因素方差分析,3组血清ALT、TBiL、ALB水平、生活质量评分差异均有统计学意义(F1=31.751,F2=4.018,F3=9.808,F4=9.681,均P<0.05),两两比较采用LSD-t检验,研究组血清ALT、TBiL水平低于对照A、B组,血清ALB水平、生活质量评分高于对照A、B组,差异均有统计学意义(均P<0.05),对照A、B组血清ALT、TBiL、ALB水平、生活质量评分比较差异均无统计学意义(均P>0.05);3组治疗期间血压升高、头痛、注射部位疼痛发生率比较差异均无统计学意义(χ21=2.056,χ22=0.414,χ23=1.014,均P>0.05).结论 对慢性乙型肝炎患者予以甘草酸二铵注射液与硫普罗宁联合治疗,可明显降低患者血清ALT、TBiL水平,提高血清ALB水平,进一步提高治疗效果,改善生活质量,且安全性较高.
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