采用纳米颗粒紧压法、离子束辅助沉积技术、表面化学处理和阳极氧化法等辅助方式将种植体表面结构进行改性。种植体植入后可能引起机体免疫反应。研究显示，多形核白细胞、巨噬细胞、单核细胞和树突细胞在机体天然免疫反应中起重要作用。这些细胞针对种植体表面分别介导不同的免疫反应。一些细胞因子参与免疫反应的调节，对于消除该区域的炎症，提高骨整合，促进伤口愈合提供帮助。本文就钛种植体表面的纳米改性方法、钛种植体表面纳米改性与机体免疫应答之间的联系等研究进展作一综述。%Nanomodifications of implant surfaces, which include nanoparticle compression, laser sintering, surface chemical process, and anodic oxidation, are widely adopted to enhance bone integration and reduce wound healing time. Many studies reveal that polymorphonuclear leukocytes and macrophages, as well as mononuclear and dendritic cells, play important roles in innate immunity. These cells are also involved in immune responses to implant surfaces. Furthermore, some cytokines can regulate immune responses to reduce inflammation, promote bone integration, and accelerate wound healing. This review presents methods of titanium implant nanomodification and the immune response of the body to nanomodified implants.
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