重症肺部感染患者血清炎性因子、凝血功能及SchE水平的变化及意义

摘要

Objective To investigate the changes of serum cytokines,coagulation parameters,serum cholinesterase (SchE) levels and their significance in patients with severe pulmonary infection.Methods To detect the changes and significance of serum inflammatory factors,coagulation function indexs and SchE levels in patients with severe pulmonary infection.Results The levels of serum IL-6,IL-8,IL-10,TNF-a,and SchE in the severe group were significantly higher than those in the normal group (P ＜0.05);The serum SchE level in the severe group was lower than in normal group.The difference was statistically significant (P ＜0.05),and the activated partial thrombin time (APTT),prothrombin time (PT),thrombin time (TT),D-Ⅱ Polymers (DD),and fibrinogen (Fib) levels were significantly higher in the severe group than in the normal group (P ＜0.05).The R value and K value of the patients were significantly higher than that of the normal group (P ＜0.05).The maximum amplitide value and the α angle of the severe group were significantly lower than the normal group,and the difference showed significant (P ＜ 0.05).Conclusions The inflammatory response is further enhanced in patients with severe pulmonary infection,coagulation disorders,serum SchE activity decreased.%目的 探讨重症肺部感染患者血清炎性因子、凝血功能指标、血清胆碱酯酶(SchE)水平的变化及其意义.方法 探讨重症肺部感染患者血清炎性因子、凝血功能指标、SchE水平的变化及其意义.结果 重症组患者的血清白细胞介素(IL-6)、IL-8、IL-10、肿瘤坏死因子α(TNF-α)水平显著的高于普通组,差异有统计学意义(P＜0.05);重症组患者的血清SchE水平显著的低于普通组,差异有统计学意义(P＜0.05);重症组患者的活化部分凝血活酶时间、凝血酶原时间、凝血酶时间、D-二聚体、纤维蛋白原水平显著的高于普通组,差异有统计学意义(P＜0.05);重症组患者的R值、K值显著的高于普通组,差异有统计学意义(P＜0.05);重症组患者的血栓弹力图最大幅度值、a角显著的低于普通组,差异有统计学意义(P＜0.05).结论 重症肺部感染患者炎症反应进一步增强、血清SchE活性降低,同时存在凝血功能的紊乱.