人类健康与肠道菌群息息相关,肠道菌群通过促进肠免疫系统发育、诱导T细胞分化等多种途径调节机体免疫功能,使之处于平衡状态,从而避免或减少免疫相关疾病的发生.过敏性疾病与自身免疫系统发育不全、免疫调控机制不完善有关,并且过敏患儿体内菌群分布及多样性较健康儿童有明显的差异,因此过敏性疾病与肠道菌群的功能状态密切相关.该文就儿童常见过敏性疾病如食物过敏、湿疹、哮喘、过敏性紫癜等与肠道菌群的相关性及作用机制进行综述.%Human health is closely related to the intestinal flora. The intestinal flora regulates the body's immune function by promoting the development of the immune system of the intestine, inducing differ-entiation of T cells, and other ways, so that it is in equilibrium, thereby avoiding or reducing the occurrence of immune-related diseases. Allergic diseases are related to incomplete development of the autoimmune system and imperfect immune control mechanisms. Moreover, the distribution and diversity of bacterial flora in chil-dren with allergies are significantly different from those in healthy children. Therefore, allergic diseases are closely related to the functional status of the intestinal flora. This review summarizes the associations and mech-anisms of common childhood allergic diseases, such as food allergies, eczema, asthma, and anaphylactoid purpura with intestinal flora.
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