儿童孤独症的发病机制

摘要

孤独症是一种起始于婴幼儿时期的严重精神神经性疾病,以社会交往、言语及行为缺陷为主要临床表现.目前,孤独症的发病率呈现逐年增高的趋势,其发病机制研究也得到了长足的发展.该文通过综述国内外孤独症的最新进展,提出兴奋性/抑制性神经递质失衡、烟酰胺代谢异常及下丘脑-垂体-肾上腺皮质轴功能紊乱是孤独症的主要发病机制.%Autistic disorder is a severe neuropsychiatric disease and abnormal development in early childhood.The main clinical manifestations of autistic disorder are social interaction,language and behavior barriers.Currently,the incidence trend has showed increased year by year,the pathogenesis of autism has also been considerable development.This paper reviews the latest developments in autism,make excitatory/inhibitory neurotransmitter imbalances,nicotinamide metabolism and HPA axis dysfunction is the main pathogenesis of autism.