原发性夜间遗尿症的治疗进展

摘要

Primary nocturnal enuresis is a common childhood disorder.This review discusses the progress on the treatment of primary nocturnal enuresis in children.Alarm interventions for nocturnal enuresis and desmopressin are the first-line therapy of primary nocturnal enuresis.In therapy-resistant cases,anticholinergic treatment combined with desmopressin can be tried.In situations when all other treatments have failed,imipramine treatment is warranted,provided the cardiac risks are taken into account.More research is needed regarding both the above drugs and non-pharmacological therapies on children with therapy-resistant enuresis.%原发性夜间遗尿症是儿童常见的一种疾病.该文综述了国内外原发性夜间遗尿症的治疗方案.遗尿警报和去氨基精加压素是原发性夜间遗尿症的一线治疗措施.治疗难治的遗尿患者可尝试使用抗胆碱能药物联合去氨基精加压素.对于其他治疗措施均无效的重型遗尿,可选用抗抑郁药丙咪嗪,但应注意其严重的心脏不良反应.对于治疗抵抗的原发性夜间遗尿症,目前需要更进一步的关于药物之间和药物和非药物治疗之间疗效的研究.