It has been well established that interactions between CD40 and CD40L,expressed in a variety of cell types including platelets,vascular endothelial cells,and immune cells,are actively involved in the development of glomerulonephritis,lupus nephritis,and the other kidney disease caused by immunological and unimmunological factors,and that tubular cells expression of CD40 was correlated well with the degree of tubulointerstitial inflammation and injury.The development of therapeutic strategies specifically accommodating CD40/CD40L seem promising against renal glomerular disease.The paper reviews the new advances in this%CD40和CD40配体表达于多种组织细胞(如血小板、血管内皮细胞、免疫细胞等),肾小管上皮细胞表达CD40可能在肾小管间质损伤中发挥重要作用.CD40L-CD40通过免疫和炎症反应参与肾小球肾炎、狼疮性肾炎的病理过程,并可能成为防治肾脏病的新靶点.该文将对近年来CD40L-CD40在肾脏病领域的研究进行综述.
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