粪便钙卫蛋白与肠道疾病相关性的研究进展

摘要

钙卫蛋白是S100蛋白家族中的一种钙、锌结合蛋白,由中性粒细胞表达,具有重要的细胞外功能.该文综述了粪便钙卫蛋白在肠道病理状态下如炎症性肠病、肠道肿瘤、坏死性小肠结肠炎、过敏相关性肠病等疾病的变化,以及对这类疾病在诊断、复发的评估及治疗的反应程度上的应用价值.%Calprotectin is a calcium-and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity.This paper reviews current findings about the implication of faecal calprotectin in the diagnosis, follow-up, assessment of relapses, and response to treatment in intestinaldiseases, such as inflammatory bowel disease, intestinal tumor, necrotizing enterocolitis, allergy and intestinal infection.