趋化因子CCL2在呼吸系统疾病中的作用

摘要

趋化因子CCL2是目前研究最广泛的趋化因子之一,在许多炎症性疾病的组织损伤和修复中均发挥重要作用.炎症发生时趋化因子CCL2主要通过识别并结合其特异性受体CCR2,将炎症信号传入细胞核内激活核转录因子,最终发挥激活及募集单核/巨噬细胞至炎症部位.该文就趋化因子CCL2在呼吸系统疾病中的最新研究进展进行综述,为临床诊断、治疗和预后提供新思路.%C-C motif chemokine ligand 2 (CCL2),one of the most widely studied chemokines,plays an important role in tissue damage and repair in many inflammatory diseases.Inflammation occurs when CCL2 mainly through the identification and combined with its specific receptor CCR2,the inflammatory signal into the nucleus to activate nuclear transcription factor,and ultimately activates and raises monocytes / macrophages to the inflammatory site.This article reviews the latest advances in chemokine CCL2 in respiratory diseases,which provides new ideas for clinical diagnosis,treatment and prognosis.