Objective:To explore the early diagnosis and management of acute fatty liver of pregnancy (AFLP) so as to improve maternal and fetal survival. Methods:The clinical findings and outcomes of pregnancy were retrospectively analyzed in 15 patients with AFLP in this hospital from January 2011 to January 2015. Results:A total of 15 AFLP manifested in the third trimester, 12 of whom were nulliparas and 3 of whom were multiparas;13 of whom were singleton pregnancy and 2 of whom were twin pregnancy. There were total 17 fetuses, 12 of whom were males and 5 of whom were females. There were 7 patients with hypertension, 9 with lower blood glucose levels, and 13 with symptoms, including nausea, vomiting and anorexia. hTe duration from admission to fetal delivery was 0.5~21.5 hours. All patients preserved their uteri, with 14 patients ending the pregnancy with cesarean section and 1 with vaginal delivery. Two patients were complicated with postpartum hemorrhage. hTere was no maternal death. Fourteen newborns were normal, 1 was asphyxia and 3 were fetal deaths. Conclusion:hTe key to improving the prognosis of both mothers and fetuses is to make early diagnosis and to end the pregnancy timely. Multimodality therapy with the help of multiple departments and the artiifcial liver support system timely are effcient in reducing the maternal mortality.%目的：探讨妊娠期急性脂肪肝(acute fatty liver of pregnancy，AFLP)的早期诊断及治疗，以降低孕产妇及围生儿的病死率。方法：对我院2011年1月至2015年1月收治的15例急性脂肪肝患者进行回顾性研究。结果：15例患者均发生于妊娠晚期，初产妇12例，经产妇3例，单胎13例，双胎2例，男胎12例，女胎5例，13例患者出现恶心，呕吐，厌食等症状。7例并发妊娠期高血压疾病。9例血糖降低，平产1例，剖宫产14例，入院至分娩时间为0.5~21.5 h。产后出血2例,无子宫切除。孕产妇死亡为0例，新生儿轻度窒息1例，死胎3例。结论：早期诊断，尽快终止妊娠是改善母儿预后的关键；多科协作，综合治疗，适时人工肝替代治疗，能有效提高产妇的生存率。
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