甘露糖结合凝集素补体途径与糖尿病肾病的相关性的研究进展

摘要

Diabetic nephropathy is one of the most important microvascular complications of diabetes, and is a significant cause of end-stage renal disease. There is evidence that the mannose binding lectin (MBL) has become a common development biomarker of diabetic nephropathy, and H-ficolin is also associated with the development of diabetic nephropathy, but the relationship between MBL associated serine protease and diabetic nephropathy remains to be further studied.%糖尿病肾病是糖尿病最严重的微血管并发症,是终末期肾病的重要病因之一.甘露糖结合凝集素(mannose-binding lectin,MBL)是糖尿病肾病发生发展重要的生物标志物,H型纤维胶原凝集素(H-ficolin)也与糖尿病肾病的发展有关,而MBL相关丝氨酸蛋白酶与糖尿病肾病的关系有待进一步研究.