α受体阻滞剂在嗜铬细胞瘤和副神经节瘤围手术期的应用

摘要

The standard treatment of pheochromocytoma and paraganglioma (PPGL) is complete surgical resection, and unavoidable intraoperative manipulation of the tumour can result in release of high-dose catecholamine (CA), which may lead to dangerous hypertension and arrhythmia, etc. In order to improve the safety of surgery, preoperative alpha-blockade was recommended for patients undergoing PPGL resection, and the most commonly used drug in clinic was alpha-adrenergic antagonists. This paper reviews the application of alpha-adrenergic antagonists in the perioperative management of PPGL.%嗜铬细胞瘤和副神经节瘤(pheochromocytoma and paraganglioma,PPGL)的标准治疗方法是完整的手术切除,术中触碰肿瘤释放的大剂量儿茶酚胺(catecholamine,CA)可能导致危险性的血压升高和心律失常等.为提高手术安全性,术前准备中推荐做CA的药物阻断处理,临床中最常用的药物为α受体阻滞剂.