中药贯叶金丝桃治疗抑郁症的进展

摘要

抑郁症患病率逐年上升,社会负担不断加重,开发抗抑郁症药物已是当务之急。贯叶金丝桃又名圣约翰草,用于抑郁症治疗已有上千年历史,是目前替代经典抗抑郁合成药物治疗轻度和中度抑郁症的唯一草药。本文通过分析贯叶金丝桃治疗抑郁症的临床疗效和作用机理,为其成为安全有效的候选药提供证据,也为我国传统抗抑郁中草药的研究和开发提供参考。With the increased prevalence of depression and social burden every year, the development of antidepressant is becoming a hop priority. Hypericum perforatum L., also known as St. John’sWort inEurope, has been used for the treatment of depression for thousands of years. It is the only herbal alternative to classic synthetic antidepressants in the therapy of mild to moderate depression. By analyzing the clinical antidepressant efficacy and mechanism of Hypericum perforatum L., it aims at providing some evidence for Hypericum perforatum L. as a safe and effective drug candidate, and also provides a reference for the research and development of our traditional antidepressant herb.