多示踪剂成像技术在肿瘤诊断方面的应用研究

摘要

全球恶性肿瘤发病率和死亡率持续升高,早期诊断对于病人预后及治疗方案的选择至关重要. 正电子发射体层成像(PET)目前已广泛用于肿瘤评价,单示踪剂PET成像为最常用的检查方法. 由于每种正电子示踪剂仅能反映一种细胞内的信息,在肿瘤诊断应用中易导致假阴性或假阳性诊断,因此需要合理联合应用多种示踪剂来提高PET在肿瘤诊断中的准确性. 对多示踪剂PET技术在肿瘤诊断方面的应用作一综述.%The incidence rate and death rate of malignant tumor are continuously increasing in the world. Early diagnosis is critical for patient prognosis and treatment options. Positron emission tomography (PET) technique has been widely used in the tumor evaluation, and single tracer PET imaging is the most commonly used inspection method. However, each positron tracer reflects specific information in the cell, which can easily lead to a false negative or false positive diagnosis. Therefore, a reasonable binding of multiple tracers is needed to improve the accuracy of PET in tumor diagnosis. In this article we reviewed the multi-tracer PET technology in tumor diagnosis application.