结构MRI对青少年癫(痐)脑皮质厚度的研究进展

摘要

Juvenile epilepsy is a syndrome with high prevalence and various seizure forms, and has great impact on the development of brain cortex as well as cognitive competence. In order to improve the diagnosis and treatment at early stage, it is essential to study the change of cortical thickness in these patients. Cortical thickness can carry useful information of brain morphologic and pathological characteristics, and is a potentially important biomarker in the diagnosis and treatment of epilepsy. This review covers the findings about the relationship between cortical thickness abnormalities and seizure duration, clinical symptoms and antiepileptic drugs of patients with juvenile epilepsy.%青少年癫(痐)发病率高,发作形式多样,对病人大脑皮质、认知能力的发育有较大影响.研究青少年癫(痐)大脑皮质厚度的变化对该病的早期诊断和治疗至关重要.大脑皮质厚度是癫(痐)诊断和治疗的重要生物特征指标,可为癫(痐)脑组织形态和病理特征研究提供依据.就结构MRI对青少年癫(痐)病人的大脑皮质厚度变化的检测及大脑皮质厚度与病程、临床症状和抗癫(痐)药的关系等方面的研究进展予以综述.