Quantitative susceptibility mapping (QSM) is a MR imaging technology based on the gradient echo se-quence. QSM reflects the difference of magnetic susceptibility between tissues by combining the magnetic map with the phase map. QSM can be quantitatively analyzed on susceptibility weighted imaging (SWI), and it has obvious advantages in detect-ing microvessels, mornitoring blood oxygen saturation, quantifying iron deposition, and identifying calcification and bleeding by measuring the susceptibility of tissues. QSM has been extensively applied in iron metabolism disease, intracranial hemor-rhage, brain tumors and cerebrovascular diseases, it has also been used in the study of abdomen, joints and cartilage, cardio-vascular and other systems. This paper introduces the principle and advantages of QSM and its clinical applications.%定量磁敏感图(QSM)是在梯度回波序列基础上,通过将幅值图与相位图融合而得到反映组织之间磁化率差异的MR成像方法.QSM在磁敏感加权成像(SWI)基础上可进行定量分析,通过测定组织磁化率值,在显示微血管、监测血氧饱和度、量化铁质沉积、鉴别钙化和出血等方面有明显优势.目前QSM在铁代谢相关性疾病、颅内出血、脑肿瘤、脑血管性疾病中已展开了大量应用及研究,其对腹部、关节和软骨、心血管等系统研究也在逐渐应用.介绍QSM的成像原理、优势及其在临床中的应用现状.
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