1749例住院新生儿TORCH感染调查与分析

摘要

目的 了解广东地区新生儿TORCH感染状况及其与疾病的关系.方法 随机采集广东省人民医院住院儿科新生儿1749例,采用酶联免疫吸附测定(ELISA)法检测TORCH-IgM抗体,450nm波长读取吸光度,以Cutoff值和1SR值判断结果.结果 新生儿TORCH-IgM总阳性率为2.17％,巨细胞病毒(CMV)、风疹病毒(RV)、弓形虫(TOX)、单纯疱疹病毒(HSV)感染率分别为1.26％、0.57％、0.17％、0.17％.在新生儿TORCH感染中,发现男性新生儿TORCH-IgM阳性率为2.31％,高于女性新生儿的1.93％.38例TORCH感染新生儿高胆红素血症、肝功能损害、贫血、心功能损伤的发病率分别为57.89％、52.63％、39.47％、10.53％.结论 加强对孕产妇进行TORCH-IgM孕前筛查宣传,减少新生儿TORCH感染,降低新生儿疾病的发生.%Objective To understand the TORCH infection status of neonates in Guangdong region and its relationship with diseases.Methods 1 749 neonates hospitalized in the pediatrics department of Guangdong provincial people's hospital were randomly collected.TORCH IgM antibody was detected by enzyme-linked immunosorbent assay(ELISA) and the absorbance values were read at a wavelength of 450 nm.Result judgments were based on Cutoff values and ISR values.Results The total positive rate of TORCH IgM of neonates was 2.17％.The infection rates of CMV,RV,TOX,HSV were 1.26％,0.57％,0.17％,0.17％,respectively.In the neonatal TORCH infecion,TORCH IgM positive rate of 2.31％ was found in male neonates,which was higher than that of 1.93 ％ in female neonates.Incidences of hyperbilirubinemia,liver function lesion,anemia and heart function damage in 38 cases of neonatal TORCH infection were 57.89 ％,52.63 ％,39.47 ％,10.53 ％,respectively.Conclusion Progestational propaganda of TORCH IgM scanning in pregnant and lying-in women should be strengthened,and neonatal TORCH infection should be decreased,in order to lower the incidence of neonatal diseases.