反复自然流产患者检测抗心磷脂抗体及IgA抗β2-GPⅠ的临床意义

摘要

Objective To combined detect the levels of anticardiolipin antibodies( ACA) and IgA anti-β2-GP I in recurrent spontaneous abortion patients. Methods 102 patients with recurrent spontaneous abortion were divided into two groups, including 57 women experienced recurrent early spontaneous abortion(gestational age shorter than 12 weeks) and 45 women experienced recurrent late spontaneous abortion(gestational age longer than or equal to 12 weeks). Normal control group included 36 normal fertile women who had no history of spontaneous abortion,fetal death and other systemic disease. ELISA had been used to determine the serum levels of ACA and IgA anti-β2-GP I . Results The positive rates of ACA-IgG, ACA-IgA, ACA-IgM were 41. 1%, 12. 7%, 15. 7% ,and the positive rate of IgA anti-β2-GP I was 36. 2% in recurrent spontaneous abortion groups. The positive rates of ACA-IgG, ACA-IgA, ACA-IgM were 40. 3% , 12. 2% , 15. 7% and the positive rate of IgA anti-β2-GP I was 36. 8% in recurrent early spontaneous abortion group. The positive rates of ACA-IgG, ACA-IgA, ACA-IgM were 42. 2%,13. 3%, 15. 5% and the positive rate of IgA anti-β2-GP I was 35. 6% in recurrent late spontaneous abortion group. The positive rates of ACA-IgG, ACA-IgA, ACA-IgM were 5. 5% ,0. 0% ,2. 7% , and the positive rate of IgA anti-β2-GP I was 8. 3% in normal control group. The positive rates of ACA-IgG, ACA-IgA, ACA-IgM and IgA anti-β2-GP I in recurrent early spontaneous abortion group and recurrent late spontaneous abortion group were significantly higher than those in normal control group(P<0. 05). The positive rates of ACA-IgG, ACA-IgA, ACA-IgM and IgA anti-β2-GP I had no significant difference between two recurrent spontaneous abortion groups (P>0. 05). Conclusion The detection of the ACA-IgG, ACA-IgA, ACA-IgM and IgA anti-β2-GP I could contribute to the diagnosis of patients with recurrent spontaneous abortion.%目的 联合检测反复自然流产患者血清抗心磷脂抗体(ACA)与IgA抗β2-糖蛋白-Ⅰ抗体(抗β2-GPⅠ)水平.方法 将102例反复自然流产患者按发生自然流产的时间分为早期流产组(孕周小于12周)57例、晚期流产组(孕周大于或等于12周)45例,另将36例健康经产妇作为健康对照组.采用ELISA法检测血清ACA和IgA抗β2-GPⅠ.结果 反复自然流产组ACA-IgG、ACA-IgA、ACA-IgM阳性率分别为41.1%、12.7%、15.7%,IgA抗β2-GPⅠ阳性率为36.2%,其中早期流产组ACA-IgG、ACA-IgA、ACA-IgM阳性率分别为40.3%、12.2%、15.7%,IgA抗β2-GPⅠ阳性率36.8%;晚期流产组ACA-IgG、ACA-IgA、ACA-IgM阳性率分别为42.2%、13.3%、15.5%,IgA抗β2-GPⅠ阳性率35.6%.健康对照组ACA-IgG、ACA-IgA、ACA-IgM阳性率分别为5.5%、0.0%、2.7%,IgA抗β2-GPⅠ阳性率8.3%.早期流产组、晚期流产组ACA-IgG、ACA-IgA、ACA-IgM和IgA抗β2-GPⅠ阳性率均显著高于健康对照组,差异有统计学意义(P<0.05).而早期流产组与晚期流产组ACA-IgG、ACA-IgA,ACA-IgM和IgA抗β2-GPⅠ阳性率差异无统计学意义(P>0.05).结论 反复自然流产患者进行ACA-IgG、ACA-IgA、ACA-IgM和IgA抗β2-GPⅠ检测有助于临床病因的诊断.