血清胱抑素C在肺癌患者肾脏功能评估中的应用价值

摘要

Objective To evaluate the serum levels of cystatin C (CysC)in lung cancer and its clinical significances for kidney assement.Methods The serum of 120 patients with lung cancer and 50 healthy controls were collected.All the patients were en-rolled in Beijing Chest Hospital,Capital Medical University,from June 2012 to October 2013.Full-automatic biochemistry analyzer was used to examine the levels of serum CysC.Results The level of serum CysC in patients with lung cancer was significantly higher than that of healthy controls(t = 4.771,P < 0.05 ).The sensitivity of CysC(81.7%)was significantly higher than that of BUN(66.7%)and Cr(45%)(χ2 =25.326,P <0.05),and there were no significantly difference of the specificity among them(χ2 =3.468,P >0.05).Conclusion Serum CysC was a useful biochemistry marker for kidney assement in lung cancer,and have better clinical significances than BUN and Cr.%目的：探讨肺癌患者血清胱抑素 C(CysC)的水平变化及在肾脏功能评估中的临床意义。方法收集2012年6月至2013年10月首都医科大学附属北京胸科医院120例肾功能损伤肺癌患者和50名健康对照者血清标本,应用全自动生化分析仪检测所有血清标本中 CysC 的水平,同时测定血清尿素氮(BUN)和肌酐(Cr)的水平。结果肺癌患者血清中 CysC 的水平显著高于健康对照组(t=4.771,P <0.05)；CysC 在肺癌中的敏感性(81.7%)显著高于 BUN(66.7%)和 Cr(45%)(χ2=25.326,P <0.05)；CysC 在肺癌中的特异度(82.2%)与 BUN(84.5%)和 Cr(88.1%)差异无统计学意义(χ2=3.468,P >0.05)。结论血清CysC 是肺癌患者肾功能损伤评估的理想生化指标,其临床应用价值优于 BUN 和 Cr。