cyfr21-1、NSE和CEA 联合检测在肺癌早期诊断及肺癌病理类型鉴别中的应用

摘要

Objective To explore the value of cyfr21‐1 ,NSE and CEA detection applied in early diagnosis of lung cancer and i‐dentification of pathological types of lung cancer .Methods Lung cancer patients (observation group) and benign lung lesions pa‐tients(control group) were selected from our hospital ,and then they cyfr21‐1、NSE and CEA value were compared and analyzed .Re‐sults The cyfr21‐1 ,NSE and CEA value of observation group were higher than control group ,and three indicators showed positive markers ,the difference was statistically significant (P<0 .05);Combined detection of three tumor markers specificity was highest , and compared to individual detection ,there were significant differences (P<0 .05);Cyfr21‐1 ,NSE and CEA levels had a certain gap in different pathological types of lung cancer patients .Conclusion Tumor markers cyfr21‐1 ,NSE and CEA have a certain reference value in the early diagnosis of lung cancer and lung pathology identification .%目的：探讨肿瘤标志物细胞角蛋白19片段21‐1（cyfr21‐1）、神经元特异性烯醇化酶（NSE）及癌胚抗原（CEA ）联合检测在肺癌早期诊断及肺癌病理类型鉴别中的应用价值。方法将来该院住院治疗的肺癌患者（观察组）和肺部良性病变者（对照组）进行对比分析，分别检测两组患者的肿瘤标志物cyfr21‐1、NSE及CEA水平。结果观察组患者较对照组血清cyfr21‐1、NSE及CEA水平明显升高，且三项指标均显示标记物阳性，差异有统计学意义（P＜0．05）；三项肿瘤标记物联合检测特异度最高，与各单项比较差异有统计学意义（P＜0．05）；观察组患者不同病理类型血清cyfr21‐1、NSE及CEA水平存在一定的差距。结论肿瘤标志物cyfr21‐1、NSE及CEA联合检测在肺癌早期诊断及肺癌病理类型鉴别中具有一定的参考价值。