交叉配合试验在肿瘤患者血小板输注中的临床应用

摘要

Objective To investigate the clinical value of platelet cross matching for platelet transfusion in patients with tumor . Methods A total of 39 cases of patients with tumors and platelet associated antibody‐positive were randomly divided into a random transfusion group and cross‐matched transfusion group ,corrected count increment(CCI) of platelet of 1 h and 24 h after transfusion were calculated ,platelet transfusion effect was determined and compared .Results CCI of 1 h and 24 h after the transfusion in the randomized transfusion group were(6 .34 ± 1 .82) × 109 /L and(3 .05 ± 1 .42) × 109 /L respectively ,and which of cross‐matched transfusion group were(15 .58 ± 3 .12) × 109 /L and(8 .13 ± 2 .55) × 109 /L ,the differences were statistically significant(P < 0 .05) . Efficiency rates of platelet transfusion were 23 .81% and 83 .33% ,14 .29% and 72 .22% ,the differences were statistically signifi‐cant(P< 0 .05) .Conclusion The efficiency of platelet transfusion can be increased significantly in patients with tumors and platelet associated antibody‐positive before transfusion by platelet cross matching .%目的：探讨血小板交叉配合试验对肿瘤患者血小板输注效果的临床价值。方法选择39例血小板相关抗体阳性的肿瘤患者，分为随机输注组与交叉配合输注组，计算输注后1 h 和24 h 血小板增加校正指数（CCI），判断血小板输注效果并进行比较分析。结果随机输注组与交叉配合输注组的1、24 h CCI 分别为（6．34±1．82）、（3．05±1．42）×109／L 与（15．58±3．12）、（8．13±2．55）×109／L ，差异有统计学意义（P＜0．05）；血小板输注有效率分别为23．81％、83．33％与14．29％、72．22％，差异有统计学意义（P＜0．05）。结论对血小板相关抗体阳性的肿瘤患者进行输注前交叉配型可显著提高血小板输注的有效性。