目的：检测慢性乙型肝炎（简称慢性乙肝）、慢性丙型肝炎（简称慢性丙肝）患者和健康人群血清中抗去唾液酸糖蛋白受体抗体（anti‐ASGPR）水平，观察anti‐ASGPR与肝炎患者疾病发展的关系。方法选取 HBV感染患者60例（慢性乙肝患者30例，慢性乙肝后肝硬化患者30例）、HCV感染患者60例（慢性丙肝患者30例，慢性丙肝后肝硬化患者30例），60例健康体检者为对照组，检测所有研究对象血清中anti‐ASGPR、ALT的水平。结果（1）HBV、HCV感染组血清anti‐ASGPR水平均比对照组明显增高，差异均有统计学意义（P＜0．01）。慢性乙肝后肝硬化组血清anti‐ASGPR水平明显比慢性乙肝组高，差异有统计学意义（P＜0．05）。慢性丙肝后肝硬化组血清anti‐ASGPR水平明显比慢性丙肝组高，差异有统计学意义（P＜0．05）。anti‐ASGPR与ALT值无相关性。（2）丙肝组anti‐ASGPR血清学水平明显高于乙肝组，差异有统计学意义（P＜0．01）。结论检测anti‐AS‐GPR有助于临床的鉴别诊断，对治疗和预后具有重要的意义。%Objective To detect the serum anti‐sialic acid glycoprotein receptor antibody (anti‐ASGPR) levels in the patients with chronic hepatitis B(CHB) ,chronic hepatitis C (CHC)and healthy people ,and to observe the relationship between anti‐ASGPR and the disease development in the patients with hepatitis .Methods Totally 60 patients with hepatitis B virus (HBV) infection(30 cases of CHB and 30 cases of CHB cirrhosis) and 60 patients with hepatitis C virus (HCV) infection(30 cases of CHC and 30 cases of CHC cirrhosis) were selected with 60 persons undergoing the physical examination as the control group .The anti‐ASGPR and ALT levels in all research subjects were detected with ELISA .Results (1)The anti‐ASGPR level in the HBV and HCV infection groups was significantly higher compared with the control group ,and the difference was statistically significant(P<0 .01) .The an‐ti‐ASGPR level in the CHB cirrhosis group was significantly higher than that in the CHB group ,and the difference was statistically significant(P<0 .05) .The anti‐ASGPR level in the CHC cirrhosis group was significantly higher than that in the CHC group ,and the difference was statistically significant(P<0 .05) .No correlation between anti‐ASGPR and ALT was found .(2) The anti‐ASG‐PR level in the CHC group was significantly higher than that in the CHB group ,and the difference was statistically significant(P<0 .01) .Conclusion The detection of anti‐ASGPR is helpful for clinical differential diagnosis and has an important significance for the treatment and prognosis .
展开▼
