Objective To understand the mycoplasma infection situation and resitance to clinical drugs among the patients with urogenital tract infection in Danzhou area .Methods A total of 1 828 patients with urogenital tract infection were selected from this area .The mycoplasma culture ,identification and drug susceptibility integration reagent kit was used for conducting the culture ,i‐dentification and drug susceptibility test of ureaplasma urealyticum (Uu) and mycoplasma hominis (Mh) .And the obtained results were statistically analyzed .Results Among 1 828 cases of urogenital tract infection ,the total positive rate of mycoplasma culture was 35 .01% (640/1 828) ,in which the male mycoplasma infection rate was 25 .94% ,while the female mycoplasma infection rate was 42 .04% .The annual mycoplasma infection rate was 30 .98% in 2014 and 38 .87% in 2015 .Mycoplasma isolated from Danzhou area still maintained a high sensitivity to doxycycline ,minocycline and josamycin .However ,it generated different levels of drug re‐sistance to quinolones antibacterial drugs .Conclusion Mycoplasma infection is common among the patients with urogenital tract in‐fection in this area ,and gradually generates drug resistance .Therefore clinical doctors should rationally select antibacterial drugs ac‐cording to the patient′s condition .%目的：了解儋州地区泌尿生殖道感染患者中支原体感染的发生情况及其对临床药物耐药性。方法选取儋州地区1828例泌尿生殖道感染患者，采用支原体培养鉴定药敏一体化试剂盒，进行解脲脲原体（U u ）和人型支原体（M h ）培养鉴定及药敏试验检测，并对结果进行统计分析。结果1828例泌尿生殖道感染者中，支原体培养总阳性率为35．01％（640／1828），其中男、女支原体感染率分别为25．94％、42．04％，2014、2015年支原体感染率分别为30．98％、38．87％。儋州地区分离的支原体对多西环素、米诺环素和交沙霉素仍保持着较高的敏感性，对喹诺酮类抗菌药物已产生不同程度的耐药性。结论儋州地区泌尿生殖道感染患者中，支原体感染已多见，并逐渐产生耐药性，临床医生在治疗时应根据患者情况合理选用抗菌药物。
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