高尿酸血症与2型糖尿病合并血管并发症的相关性研究

摘要

目的：探讨高尿酸血症和合并2型糖尿病患者血管并发症的相关危险因素。方法选取体检健康者97例纳入对照组，单纯2型糖尿病组103例和2型糖尿病合并高尿酸血症组78例。比较3组受试者空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL‐C）、低密度脂蛋白胆固醇（LDL‐C）、载脂蛋白（Apo）A1、ApoB 、肌酐（Cr）、尿酸（UA），同时留取晨尿检测尿微量清蛋白（UMA）及体质量指数（BMI），并研究高尿酸血症和糖尿病相关并发症的相关性。结果单纯2型糖尿病组 FPG 、TG 、Cr 、UMA 、HbA1c 水平均高于对照组（P ＜0．05）；2型糖尿病合并高尿酸血症组 BMI 、FPG 、TG 、TC 、LDL‐L 、UMA 、Cr 、HbA1c 均高于对照组（P＜0．05）；2型糖尿病合并高尿酸血症组 BMI 、TG 、Cr 、UMA 、HbA1c 均高于单纯2型糖尿病组（P＜0．05）。2型糖尿病合并高尿酸血症组患者的糖尿病肾病、下肢动脉斑块发病率明显高于单纯2型糖尿病组，差异有统计学意义（P＜0．05）。结论2型糖尿病合并高尿酸血症组患者比单纯2型糖尿病患者更易发生血脂异常，2型糖尿病合并高尿酸血症组患者糖尿病肾病、下肢动脉斑块发病率也明显高于单纯2型糖尿病患者。%Objective To investigate the risk factors of hyperuricemia and type 2 diabetes mellitus(T2DM ) with vascular com‐plication .Methods 97 individuals undergoing the physical examination were included into the control group ,103 patients with pure T2DM and 78 patients with T2DM complicating hyperuricemia were selected .The fasting plasma glucose(FPG) ,glycosylated he‐moglobin(HbA1c) ,total cholesterol(TC) ,triglycerides(TG) ,high density lipoprotein cholesterol (HDL‐C) ,low density lipoprotein cholesterol (LDL‐C) ,apolipoprotein A1(ApoA1) ,apolipoprotein B (ApoB) ,serum creatinine (Cr) and uric acid (UA ) were com‐pared among 3 groups ,meanwhile the first morning urine was collected for detecting urine microalbumin (UMA) ,and the body mass index(BMI) was detected .Then the correlation between hyperuricemia with the diabetes related complications was investigated .Re‐sults The levels of FPG ,TG ,Cr ,UMA and HbA1c in the pure T2DM group were higher than those in the control group(P < 0 . 05) ;BMI ,FPG ,TG ,TC ,LDL‐L ,UMA ,Cr and HbA1c in the T2DM complicating hyperuricemia group were higher than those in the control group (P < 0 .05) ;BMI ,TG ,Cr ,UMA and HbA1c in the T2DM complicating hyperuricemia group were higher than those in the pure T2DM group(P < 0 .05) .The incidence rates of diabetic nephropathy (DN ) ,limb arterial plaques in the T2DM complicating hyperuricemia group were significantly higher than those in the T 2DM group ,the differences were statistically signifi‐cant (P< 0 .05) .Conclusion The patients with T2DM complicating hyperuricemia are easier to develop dyslipidemia ,and their inci‐dence rates of DN and lower limb arterial plaque are also significantly higher than those in patients with pure T 2DM .