降钙素原与超敏C反应蛋白检测在高胆红素血症早产儿合并感染诊断中的价值

摘要

Objective To investigate the value of procalcitonin (PCT ) and high sensitive C reactive protein (Hs-CRP) in the diagnosis of hyperbilirubinemia premature infant complicating infection .Methods A total of 192 cases of hyperbilirubinemia premature infants in our hospital were selected as the research subjects and divided into the infection group and non-infection group ac-cording to the clinical diagnostic results .The levels of WBC ,Hs-CRP ,PCT and total bilirubin(TB) were measured and performed the comparative analysis .Results The Hs-CRP ,PCT and TB levels in the infection group were significantly higher than those in the non-infected group ,the difference was statistically significant (P＜0 .05);while there was no significant difference in WBC count between the two groups(P＞0 .05) .PCT had higher sensitivity and specificity than Hs-CRP in the diagnosis of infection .The positive rates of PCT and Hs-CRP in the infection group were significantly higher than those in the non-infection group ,the difference was statistically significant (P＜0 .05) .Conclusion PCT and Hs-CRP can guide the early diagnosis of hyperbilirubinemia premature infant complicating infection and are conducive to early treatment and rehabilitation of the neonatal patients .%目的 探讨降钙素原(PCT)与超敏C反应蛋白(Hs-CRP)检测在高胆红素血症早产儿合并感染诊断中的价值.方法 选取该院就诊的192例高胆红素血症早产儿为研究对象,根据临床诊断结果分为感染组及非感染组,测定两组白细胞(WBC)、Hs-CRP、PCT和总胆红素(TB)水平,并进行比较分析.结果 感染组Hs-CRP、PCT和TB水平明显高于非感染组,差异有统计学意义(P<0.05);两组WBC水平比较差异无统计学意义(P>0.05).在感染诊断中,PCT比Hs-CRP具有更高的灵敏性及特异性.感染组PCT、Hs-CRP阳性率明显高于非感染组,差异有统计学意义(P<0.05).结论 PCT、Hs-CRP可早期指导诊断高胆红素血症早产儿合并感染,有助于患儿的早期治疗和康复.