BNP等指标在心血管疾病诊疗中的临床意义

摘要

目的 探讨脑钠肽(BNP)、尿酸(UA)、乳酸脱氢酶(LDH)和肌钙蛋白T(TnT)检查指标在心血管疾病诊断及预后观察中的作用.方法 选取心血管疾病患者271例和非心血管疾病患者271例分别作为心血管疾病组和对照组,并将心血管疾病组按照民族类型进一步分为维吾尔族心血管疾病组和汉族心血管疾病组,检测所有研究对象BNP、LDH、UA和TnT水平,对检测结果进行统计分析.结果 心血管疾病组BNP、UA、LDH和TnT水平明显高于对照组,差异有统计学意义(P<0.05);维吾尔族心血管疾病组LDH、TnT水平高于汉族心血管疾病组,汉族心血管疾病组BNP、UA水平高于维吾尔族心血管疾病组,差异均无统计学意义(P>0.05);心力衰竭、冠心病患者治疗1周后BNP水平下降最明显,且与治疗前比较差异有统计学意义(P<0.05);心力衰竭患者治疗1周后UA水平与治疗前比较差异有统计学意义(P<0.05).结论 BNP、UA、LDH和TnT联合检测在心血管疾病的早期诊断、治疗及预后观察中有重大临床意义.%Objective To investigate the effect of brain natriuretic peptide (BNP) ,uric acid (UA) ,lactic dehydrogenase(LDH) and troponin T (TnT)in the diagnosis and prognosis observation of cardiovascular disease .Methods A total of 271 cases of cardio-vascular diseases and 271 cases of non-cardiovascular diseases were selected as the cardiovascular diseases group and control group respectively ,moreover the cardiovascular diseases group was further divided into the Uyghur cardiovascular diseases group and Han cardiovascular diseases group according to the nationality type .The levels of BNP ,LDH ,UA and TnT were detected in all cases . Then the detection results were statistically analyzed .Results The levels of BNP ,UA ,LDH and TnT in the cardiovascular diseases group were significantly higher than those in the control group ,the difference was statistically significant (P<0 .05);the LDH and TnT levels in the Uyghur cardiovascular diseases group were higher than those in the Han cardiovascular diseases group ,while the BNP and UA levels in the Han cardiovascular diseases group were higher than those in the Uyghur cardiovascular diseases group , the difference was not statistically significant (P>0 .05);the decrease after 1 week treatment in the patients with heart failure and coronary heart disease was most significant ,which showed statistical difference compared with before treatment (P<0 .05);the UA level after 1 week treatment in heart failure patients had statistical difference compared with before treatment (P<0 .05) .Conclu-sion The combined detection of BNP ,LDH ,UA and TnT has an important clinical significance in early diagnosis ,treatment and prognosis of cardiovascular diseases .