高压氧对急性脑出血大鼠血浆降钙素基因相关肽及内皮素的影响

摘要

Objective To investigate the effects of hyperbaric oxygen (HBO) on plasma calcitonin gene-re-lated peptide and endothelin in rats with acute cerebral hemorrhage.Methods 56 rats were randomly divided into normal group,acute cerebral hemorrhage group (divided into groups of 4,24,48 h groups after cerebral hemorrhage) and hyperbaric oxygen treatment group (divided into groups of 4,24 and 48 h group after cere-bral hemorrhage).In addition to the normal group,other rats in each group were treated with in an acute cere-bral hemorrhage model.The effects of HBO on plasma calcitonin gene-related peptide and endothelin in rats with acute cerebral hemorrhage were observed and compared.Results After acute cerebral hemorrhage,the levels of plasma and hemorrhage cortical endothelin in subgroups of 4,24,48 h after endothelin were signifi-cantly higher than those in the normal group,and the level of the 24 h of the nemorrhage group was the high-est.The levels of calcitonin gene-related peptide in plasma and hemorrhagic cortex decreased significantly in 4, 24 and 48 h groups compared with the normal group,and the level in the 48 h group was the lowest.After hy-perbaric oxygen therapy,the levels of plasma and cerebral hemorrhage in the 4,24 and 48 h groups were signif-icantly lower than those in the corresponding cerebral hemorrhage group,and differences were statistically sig-nificant (P<0.05);calcitonin gene gene-related peptide and cerebral hemorrhage were significantly higher than those in the corresponding cerebral hemorrhage groupc,and the differences were statistically significant (P<0.05).Conclusion Hyperbaric oxygen has a therapeutic effect on the elevation of endothelin and the decrease of calcitonin gene-related peptide in patients with acute cerebral hemorrhage.%目的 探讨高压氧对急性脑出血大鼠血浆降钙素基因相关肽及内皮素的影响.方法 将大鼠分为正常组、急性脑出血组(分为脑出血后4、24、48 h亚组)、高压氧治疗组(分为脑出血后4、24、48 h亚组).除正常组外,其他各组大鼠建立急性脑出血大鼠模型,对比观察高压氧对急性脑出血大鼠血浆降钙素基因相关肽及内皮素的影响.结果 急性脑出血后,血浆及出血皮层内皮素在出血后4、24、48 h亚组的水平较正常组大鼠明显增高,其中出血后24 h亚组水平最高;血浆中降钙素基因相关肽在4、24、48 h亚组的水平较正常组大鼠明显降低,且48 h亚组水平最低;急性脑出血大鼠经高压氧治疗后4、24、48 h各亚组血浆及出血皮层内皮素水平与相应急性脑出血组相比均显著下降,差异具有统计学意义(P<0.05);降钙素基因相关肽水平与相应急性脑出血组相比均显著增高,差异有统计学意义(P<0.05).结论 对于急性脑出血引起的内皮素升高及血浆降钙素基因相关肽降低,高压氧有治疗作用.