血清IL-18、IL-22、IL-23表达在类风湿性关节炎中的意义

摘要

目的 探讨血清白细胞介素(IL)-18、IL-22、IL-23表达在类风湿性关节炎中的意义.方法 选择2014年12月至2016年12月该院就诊的40例类风湿性关节炎患者,并选择同期该院进行体检的40例健康人群作为对照组,比较两组受试者血清IL-18、IL-22、IL-23的表达水平,并分析血清IL-18、IL-22、IL-23和类风湿性关节炎病情严重程度、治疗前后及临床指标的关系.结果 类风湿性关节炎组血清IL-18[(741.82 ± 45.60) pg/mL]、IL-22[(62.34 ± 3.72)pg/mL]、IL-23[(141.73 ± 18.31)pg/mL]水平显著高于对照组[(231.28 ± 26.71)、(37.26 ± 3.91)、(48.28 ± 5.70)pg/mL],且差异具有统计学意义(P<0.05);高度活动组类风湿性关节炎患者血清IL-18、IL-22、IL-23明显高于中度活动组和稳定/轻度活动组,中度活动组血清IL-18、IL-22、IL-23明显高于稳定/轻度活动组,且差异均具有统计学意义(P<0.05);类风湿性关节炎患者治疗后血清IL-18、IL-22、IL-23均明显比治疗前低,且差异具有统计学意义(P<0.05);相关性分析显示,血清IL-18和关节压痛指数、关节肿胀指数、C反应蛋白、骨质破坏评分之间呈正相关(P<0.05),血清IL-22、IL-23和晨僵时间、视觉模拟评分法(VAS)评分、关节压痛指数、关节肿胀指数、血小板计数、C反应蛋白、骨质破坏评分之间呈正相关(P<0.05).结论 血清IL-18、IL-22、IL-23和类风湿性关节炎疾病严重程度之间存在着密切的关系,可随着疾病加重表达随之升高,同时也利于评估疾病治疗疗效,应用价值较高.%Objective To study the significance of serum interleukin(IL)-18,IL-22 and IL-23 levels in rheumatoid arthritis.Methods 40 patients of rheumatoid arthritis w ho received therapy from December 2014 to December 2016 in our hospital were selected,and 40 cases of healthy people in our hospital for the same pe-riod were selected as a control group,the expressions of serum IL-18,IL-22 and IL-23 were compared between the two groups;The relationship between the serum IL-18,IL-22,IL-23 and the severity of rheumatoid arthri-tis,before and after treatment and clinical indicators were analyzed.Results The serum IL-18[(741.82 ± 45.60)pg/mL],IL-22[(62.34 ± 3.72)pg/mL]and IL-23[(141.73 ± 18.31)pg/mL]in rheumatoid arthritis group were higher than that of control group[(231.28 ± 26.71),(37.26 ± 3.91),(48.28 ± 5.70)pg/mL],and the difference has statistical significance(P<0.05);the serum IL-18,IL-22 and IL-23 in highly active group rheumatoid arthritis patients were significantly higher than that of moderate active group and stable/mild ac-tive group,serum IL-18,IL-22 and IL-23 in the moderate active group were significantly higher than that of stable/mild active group,and the difference has statistical significance(P<0.05);after treatment,the serum levels of IL-18,IL-22 and IL-23 in patients with rheumatoid arthritis were significantly lower than those before treatment,and the difference has statistical significance(P< 0.05);the results of correlation analysis show that there was a positive correlation between the serum IL-18 and joint tenderness index,joint swelling index, C reactive protein and bone destruction score(P<0.05),and there was a positive correlation between the ser-um IL-22,IL-23 and VAS score,the time of morning stiffness,joint pain index,swelling index,platelet count,C reaction protein and done destruction score(P<0.05).Conclusion The serum IL-18,IL-22,and IL-23 are closely related to the severity of rheumatoid arthritis,which can increase with the aggravation of disease,and it also helps to assess the effectiveness of disease treatment,application value is high.