Objective: To investigate intestinal permeability inpatients with portal hypertension and its relationshipwith portal pressure.Methods: Twenty patients with portal hypertensionwere divided into two groups (A, B), 10 patients pergroup. In group A, patients were treated with com-bined transjugular intrahepatic portosystemic shunt(TIPS) and modified Sugiura. In group B, patientswere treated with modified Sugiura only. Intestinalpermeability was assessed before operation, twoweeks after TIPS. and two weeks after modified Sug-iura; 20 healthy control subjects were also assessed.Results: Intestinal permeability was significantlyhigher in the patients than in the control group (P0. 01). In group A, portal pressure, intestinal per-meability decreased two weeks after TIPS (P0. 05), and no obvious change was noted two weeksafter modified Sugiura; but they were significantlylower than those before TIPS (P0. 05). In groupB, intestinal permeability was not different beforeand after operation. Intestinal permeability in groupA was not different from that in group B beforetreatment, but significantly lower after modified Su-giura (P0. 05). Portal pressure was significantlycorrelated with intestinal permeability (r=0. 627, P0. 01).Conclusions: This study shows that combined TIPSand modified Sugiura can lower portal pressure andintestinal permeability, and enhance the therapeuticefficacy on portal hypertension.
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