Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease:Potential therapeutic implications

摘要

To the Editor:We read with considerable interest the paper of Shree Harini and Ezhilarasan,summarizing the possible pathophysiological con-nections between the modulators of canonical Wnt/β-catenin pathway and nonalcoholic fatty liver disease(NAFLD)[1].The au-thors supported with evidence that Wnt/β-catenin signaling con-tributes to hepatic homeostasis by regulating hepatic development,regeneration and metabolism.They also supported that dysregula-tion of modulators of Wnt/β-catenin signaling is not only impli-cated in the development of NAFLD,but also in its progression to nonalcoholic steatohepatitis(NASH),hepatic fibrosis and hepato-cellular carcinoma(HCC).