自身免疫与糖尿病大血管病变

摘要

糖尿病大血管病变是以动脉粥样硬化为主要病理特征的糖尿病慢性并发症之一.近年来,自身免疫因素在动脉粥样硬化发病中的作用越来越受到关注,多种自身抗体、自身抗原和免疫系统成分参与动脉粥样硬化的发生和发展.检测血液中几种自身抗原及其抗体,如氧化型低密度脂蛋白、p2糖蛋白Ⅰ、热休克蛋白的变化,可间接预测糖尿病患者动脉粥样硬化的发生、发展.对糖尿病大血管病变相关自身免疫更深入的研究,将为糖尿病大血管病变的早期诊断、监测和治疗开辟一条新的途径.%Diabetic macrovascular complication characterized by atherosclerosis is one of most common chronic complications of diabetes.Recently,the role of autoimmunity in the development of atherosclerosis is payed more and more attention.Many autoantigens,autoantibodies and immunologic factors are involved in the occurrence and development of atherosclerosis.Detecting some autoantigens and their antibodies,such as oxidized low-density lipoprotein,beta 2-glyeoprotein Ⅰ,heat shock proteins,could predict the development of atherosclerosis in diabetic patients.Along with more and more researches in autoimmunity of diabetic macrovascular complication,new pathways for early diagnosis,monitor and intervention of diabetic macrovascular complication would be found.