慢性脑灌注不足与血管性认知损害

摘要

慢性脑灌注不足(chronic cerebral hypoperfusio,CCH)是导致血管性认知损害(vascular cognitive impairment,VCI)的重要因素,与无症状脑梗死、脑白质疏松等小血管病变密切相关.VCI具体机制尚未明确,CCH表现也存在较大差异.文章从动物模型、灌注表现、病理生理学机制等方面对CCH与VCI的关系进行了综述.%Chronic cerebral hypoperfusion (CCH) is an important factor leading to vascular cognitive impairment (VCI).It is closely related to small vessel disease such as asymptomatic cerebral infarction and leukoaraiosis.The specific mechanism of VCI remains unclear.The manifestations of CCH are also quite different.This article reviews the relationship between CCH and VCI from animal models,perfusion performance,and pathophysiological mechanisms,etc.